Biochemical Reaction Engineering
Biokemisk reaktionsteknik

KETN30F, 7.5 högskolepoäng

Gäller från och med: Autumn 2018
Beslutad av: Margareta Sandahl
Datum för fastställande: 2018-09-06

Allmänna uppgifter

Avdelning: Chemical Engineering
Kurstyp: Gemensam kurs, avancerad nivå och forskarnivå
Kursen ges även på avancerad nivå med kurskod: KETN30
Undervisningsspråk: English

Syfte

Development of new biotechnical processes requires analysis of the microbial metabolism as well as the bioreactor. The aim of this course is to provide the student with understanding and skills to enable them to analyse a biotechnical process in a quantitative fashion. This will provide the basis for the design and scale-up of processes in biotechnology.

Mål

Kunskap och förståelse

För godkänd kurs skall doktoranden

• be able to describe the principles behind global metabolic networks analysis, and describe the application of metabolic network analysis in the design of genetically modified production organisms
• be able to describe the interaction between physical transport phenomena and the microbial metabolism in a bioreactor
• be able to identify critical factors in the scale-up of processes in biotechnology, and qualitatively compare different process options

Färdighet och förmåga

För godkänd kurs skall doktoranden

• be able to quantitatively analyse experimental results on the macro-level, e.g. by making carbon- and degree of reduction balances
• be able to set up stoichiometric network models for metabolic networks
• be able to model microbial kinetics
• be able to execute reaction engineering calculations for the design of bioreactors, including size, stirrer effect, mass transfer capacity, and cooling requirements
• be able to make a reasonable choice of reactor, substrate, and production organism for a given biotechnical process

Värderingsförmåga och förhållningssätt

För godkänd kurs skall doktoranden be able to assess the usefulness of quantitative models of biological processes within the research topic of the PhD student

Kursinnehåll

The course treats processes in biotechnology in a quantitative fashion on both the cellular and the reactor level. The following topics are covered: Metabolic reactions, stoichiometry, the C-mol concept, degree of reduction, thermodynamics in microbial systems, modelling of metabolic networks, reaction kinetics, design of biotechnical processes, mass transfer, and scale-up of biotechnical processes.

Kurslitteratur

Villadsen, J., Nielsen, J. & Lidén, G.: Bioreaction Engineering Principles. Springer, 2011. ISBN 9781441996879.

Kursens undervisningsformer

Undervisningsformer: Föreläsningar, seminarier, övningar, studiebesök. This is also an advanced course within the engineering programmes of the Faculty of Engineering (B and K)

Kursens examination

Examinationsformer: Skriftlig tentamen, inlämningsuppgifter
Betygsskala: Underkänd, godkänd
Examinator:

Antagningsuppgifter

Förkunskapskrav: Accepted to graduate studies within chemistry, chemical engineering, biotechnology or closely related fields
Förutsatta förkunskaper: Basic biochemistry (e.g. KBKA/KBK011), Reaction engineering (e.g. KETF25 or KETF40/KTE170) and linear algebra (e.g. FMAA20)

Övrig information

Contact: Gunnar Liden, Chemical engineering gunnar.liden@chemeng.lth.se

Kurstillfällesinformation

Kontaktinformation och övrigt

Kursansvariga:
Hemsida: https://liveatlund.lu.se