KAS003F

Temporary

Advanced Organic Synthesis

7.5

Third-cycle course

7719 (Centre for Analysis and Synthesis (CAS))

 -09-19

Mats Ohlin

English

If sufficient demand

The course aims to deepen and broaden the students knowledge of modern synthetic methods. The course will broadly cover synthetic methods with respect to their mechanisms and frontier orbital descriptions. Specifically, the course will cover oxidations and reductions, functional group interconversions, carbon-carbon bond forming reactions, fundamental transition metal catalysis, cycloadditions, rearrangements, aromatic chemistry, and vissa applications in multi-step synthesis.

Lectures are given on broadly selected topics in advanced organic synthesis. A mandatory seminar is associated with each lecture. Assignments for the seminars will be handed out. Individual hand in assignments may replace or compliment seminars. Each student will present a 25 minute in-depth lecture on a topic within the course. Part of the presentation assignment is to give constructive feedback on a peer presentation.

describe a broad range of organic reactions using arrow mechanisms and frontier orbital theory.
describe how different reagents and conditions can be used to influence the chemo- and diastereoselectivity of organic reactions.

apply insight in reaction mechanisms and frontier orbital theory to predict reaction outcomes in terms of chemo- regio-, and diastereoselectivity.
apply modern chemical reactions to propose resonable multi-step synthetic routes to defined target molecules of moderate complexity.

evaluate the choice of a particular reagent or strategy for a given synthetic problem.
evaluate different synthetic approaches from a chemo- and stereoselectivity perspective.
discuss the scope and limitations of reactions in organic synthesis.

Lectures

Seminars

Exercises

Project

Self-study literature review

Written exam

Written report

Written assignments

Seminars given by participants

Miscellaneous

Active participation in lectures, seminars, and exercises (passed/not passed).
Attendance on presentation assignments by other students (passed/not passed)

Failed, pass

Admitted to PhD education

KEMM01 or equivalent. Formative exams may be used to evaluate adequate prior knowledge.

None. All students are admitted.

Carey, F. A. & Sunberg, R. J.: Advanced Organic Synthesis. Springer, 2007. ISBN 9780387683546.

The course is given if the participants are at least five students

KAS003F

 -09-19

Mats Ohlin