Advanced Organic Synthesis
Avancerad organisk syntes

KAS003F, 7.5 credits

Valid from: Autumn 2018
Decided by: Mats Ohlin
Date of establishment: 2018-09-19

General Information

Division: Centre for Analysis and Synthesis (CAS)
Course type: Third-cycle course
Teaching language: English

Aim

The course aims to deepen and broaden the students knowledge of modern synthetic methods. The course will broadly cover synthetic methods with respect to their mechanisms and frontier orbital descriptions. Specifically, the course will cover oxidations and reductions, functional group interconversions, carbon-carbon bond forming reactions, fundamental transition metal catalysis, cycloadditions, rearrangements, aromatic chemistry, and vissa applications in multi-step synthesis.

Goals

Knowledge and Understanding

For a passing grade the doctoral student must

• describe a broad range of organic reactions using arrow mechanisms and frontier orbital theory.
• describe how different reagents and conditions can be used to influence the chemo- and diastereoselectivity of organic reactions.

Competences and Skills

For a passing grade the doctoral student must

• apply insight in reaction mechanisms and frontier orbital theory to predict reaction outcomes in terms of chemo- regio-, and diastereoselectivity.
• apply modern chemical reactions to propose resonable multi-step synthetic routes to defined target molecules of moderate complexity.

Judgement and Approach

For a passing grade the doctoral student must

• evaluate the choice of a particular reagent or strategy for a given synthetic problem.
• evaluate different synthetic approaches from a chemo- and stereoselectivity perspective.
• discuss the scope and limitations of reactions in organic synthesis.

Course Contents

Lectures are given on broadly selected topics in advanced organic synthesis. A mandatory seminar is associated with each lecture. Assignments for the seminars will be handed out. Individual hand in assignments may replace or compliment seminars. Each student will present a 25 minute in-depth lecture on a topic within the course. Part of the presentation assignment is to give constructive feedback on a peer presentation.

Course Literature

Carey, F. A. & Sunberg, R. J.: Advanced Organic Synthesis. Springer, 2007. ISBN 9780387683546.

Instruction Details

Types of instruction: Lectures, seminars, exercises, project, self-study literature review

Examination Details

Examination formats: Written exam, written report, written assignments, seminars given by participants, miscellaneous. Active participation in lectures, seminars, and exercises (passed/not passed). Attendance on presentation assignments by other students (passed/not passed)
Grading scale: Failed, pass
Examiner: Professor Ulf Nilsson

Admission Details

Admission requirements: Admitted to PhD education
Assumed prior knowledge: KEMM01 or equivalent. Formative exams may be used to evaluate adequate prior knowledge.
Selection criteria: None. All students are admitted.

Further Information

The course is given if the participants are at least five students

Course Occasion Information

Start date: 2024-03-01. Start date is approximate.
End date: 2024-08-30
Course pace: 25% of full time

Contact and Other Information

Course coordinators:

• Ulf Nilsson <ulf.nilsson@chem.lu.se>
• Kenneth Wärnmark <kenneth.warnmark@chem.lu.se>