Advanced Organic Synthesis
Avancerad organisk syntes

KAS003F, 7.5 högskolepoäng

Gäller från och med: Autumn 2018
Beslutad av: Mats Ohlin
Datum för fastställande: 2018-09-19

Allmänna uppgifter

Avdelning: Centre for Analysis and Synthesis (CAS)
Kurstyp: Ren forskarutbildningskurs
Undervisningsspråk: English

Syfte

The course aims to deepen and broaden the students knowledge of modern synthetic methods. The course will broadly cover synthetic methods with respect to their mechanisms and frontier orbital descriptions. Specifically, the course will cover oxidations and reductions, functional group interconversions, carbon-carbon bond forming reactions, fundamental transition metal catalysis, cycloadditions, rearrangements, aromatic chemistry, and vissa applications in multi-step synthesis.

Mål

Kunskap och förståelse

För godkänd kurs skall doktoranden

• describe a broad range of organic reactions using arrow mechanisms and frontier orbital theory.
• describe how different reagents and conditions can be used to influence the chemo- and diastereoselectivity of organic reactions.

Färdighet och förmåga

För godkänd kurs skall doktoranden

• apply insight in reaction mechanisms and frontier orbital theory to predict reaction outcomes in terms of chemo- regio-, and diastereoselectivity.
• apply modern chemical reactions to propose resonable multi-step synthetic routes to defined target molecules of moderate complexity.

Värderingsförmåga och förhållningssätt

För godkänd kurs skall doktoranden

• evaluate the choice of a particular reagent or strategy for a given synthetic problem.
• evaluate different synthetic approaches from a chemo- and stereoselectivity perspective.
• discuss the scope and limitations of reactions in organic synthesis.

Kursinnehåll

Lectures are given on broadly selected topics in advanced organic synthesis. A mandatory seminar is associated with each lecture. Assignments for the seminars will be handed out. Individual hand in assignments may replace or compliment seminars. Each student will present a 25 minute in-depth lecture on a topic within the course. Part of the presentation assignment is to give constructive feedback on a peer presentation.

Kurslitteratur

Carey, F. A. & Sunberg, R. J.: Advanced Organic Synthesis. Springer, 2007. ISBN 9780387683546.

Kursens undervisningsformer

Undervisningsformer: Föreläsningar, seminarier, övningar, projekt, litteraturkurs som självstudier

Kursens examination

Examinationsformer: Skriftlig tentamen, skriftlig rapport, inlämningsuppgifter, seminarieföredrag av deltagarna, övrigt. Active participation in lectures, seminars, and exercises (passed/not passed). Attendance on presentation assignments by other students (passed/not passed)
Betygsskala: Underkänd, godkänd
Examinator: Professor Daniel Strand

Antagningsuppgifter

Förkunskapskrav: Admitted to PhD education
Förutsatta förkunskaper: KEMM01 or equivalent. Formative exams may be used to evaluate adequate prior knowledge.
Urvalskriterier: None. All students are admitted.

Övrig information

The course is given if the participants are at least five students

Kurstillfällesinformation

Startdatum: 2018-09-18. Startdatumet är ungefärligt.
Slutdatum: 2019-01-31
Kursfart: 25% of full time

Kontaktinformation och övrigt

Kursansvariga:

• Ulf Nilsson <ulf.nilsson@chem.lu.se>
• Kenneth Wärnmark <kenneth.warnmark@chem.lu.se>