NMR Spectroscopy for Synthetic Chemists
NMR-spektroskopi för synteskemister

KAS025F, 5 credits

Valid from: Spring 2024
Decided by: Jens Wahlström
Date of establishment: 2024-04-09

General Information

Division: Centre for Analysis and Synthesis (CAS)
Course type: Third-cycle course
Teaching language: English

Aim

There is no course for doctoral students that covers NMR spectroscopy without extensive mathematics. This course fulfils a long-awaited need for chemists who use NMR spectroscopy but do not require the quantum chemical background provided in the KFKN01F course.

Goals

Knowledge and Understanding

For a passing grade the doctoral student must

• Understand and explain the basic principles of nuclear magnetic resonance spectroscopy (NMR spectroscopy), including a vector-based description of NMR pulses.
• Have knowledge of how nuclear magnetic resonance can be used to study the dynamics of molecules.
• Have knowledge of the most common multidimensional NMR experiments and the principles of their use in determining the structures of organic and organometallic molecules.

Competences and Skills

For a passing grade the doctoral student must

• Calibrate and optimize the common parameters in pulse sequences.
• Interpret information from the most common one- and multidimensional NMR experiments.
• Describe a molecule's dynamic and structural properties based on NMR data.
• Independently perform NMR experiments with limited guidance.
• Clearly present results and interpretations of NMR experiments both orally and in writing.

Judgement and Approach

For a passing grade the doctoral student must Choose the NMR technique that is best suited for studying a given structural or dynamic problem.

Course Contents

The aim is to provide fundamental knowledge in nuclear magnetic resonance (NMR) and a solid understanding of how the technique can be employed to study the structure and dynamics of small molecules. The course covers methods focused on organic and organometallic molecules. The course begins with the fundamental theory of nuclear magnetic resonance. It is followed by lectures on chemical shift, nuclear spin interactions, spin dynamics, chemical exchange, relaxation, and multidimensional applications. Finally, each student completes a project where a molecule's structure is studied using various NMR methods. The focus of this project may vary depending on the student's specialization.

Course Literature

Claridge, Timothy D.W.: High-Resolution NMR Techniques in Organic Chemistry. Elsevier Science.

Instruction Details

Types of instruction: Lectures, seminars, exercises, project. Participation in exercises and seminars is mandatory.

Examination Details

Examination formats: Written exam, written report, written assignments, seminars given by participants
Grading scale: Failed, pass
Examiner:

Admission Details

Assumed prior knowledge: Master degree knowledge of inorganic and organic chemistry

Further Information

At least 5 students needed

Course Occasion Information

Contact and Other Information

Course coordinators: