Gäller från och med: Autumn 2020
Beslutad av: Margareta Sandahl
Datum för fastställande: 2020-03-19
Avdelning: Biophysical Chemistry
Kurstyp: Ren forskarutbildningskurs
Undervisningsspråk: English
The aim of the course is for the student to acquire advanced knowledge about Nuclear Magnetic Resonance (NMR) theory and applications in studies of bio-macromolecular structure and dynamics. The course focuses on methods for studying proteins, but the underlying theory is equally applicable to essentially any molecule in the liquid phase.
Kunskap och förståelse
För godkänd kurs skall doktoranden
Färdighet och förmåga
För godkänd kurs skall doktoranden
Värderingsförmåga och förhållningssätt
För godkänd kurs skall doktoranden
The course begins with basic theory on NMR, including an introduction to quantum mechanics, quantum statistical mechanics, the density matrix and product operator formalisms. The course then covers the theory of multi-dimensional spectroscopy, including frequency labeling of coherences, coherence transfer and mixing, and coherence pathway selection. The course also covers experimental techniques and practical aspects, including data acquisition and data processing.
J, C., WJ, F., AG, P., M, R. & NJ, S.: Protein NMR Spectroscopy. Principles and Practice, 2nd Edition. Elsevier Academic Press, 2007. ISBN 9780121644918.
The textbook will be complemented with review articles distributed during the course.
Undervisningsformer: Seminarier, projekt, litteraturkurs som självstudier. The course is organized around seminars or discussion meetings where groups of students present the assigned reading material. The course also includes a project, where each student will analyze an NMR pulse sequence from the research literature.
Examinationsformer: Skriftlig rapport, inlämningsuppgifter.
Students will solve home assignments during the course.
At the end of the course, each student will be assigned a recent research publication, which should be analyzed in detail using the theory learnt in the course and described in a written report.
Betygsskala: Underkänd, godkänd
Examinator: Professor Mikael Akke
Förkunskapskrav: KFKN01, Magnetic Resonance — Spectroscopy and Imaging, or an equivalent course.
Förutsatta förkunskaper: Mathematics corresponding to curriculum in the K or B programs at LTH.
The course will be offered provided that a sufficient number of students have shown an interest. Normally, this would entail at least 3-4 students in order for the peer instruction element to work well.
Startdatum: 2024-04-15
Slutdatum: 2024-06-20
Kursfart: Full time
Kursansvarig: Mikael Akke <mikael.akke@bpc.lu.se>