Gäller från och med: Spring 2021
Beslutad av: Margareta Sandahl
Datum för fastställande: 2020-03-19
Avdelning: Biophysical Chemistry
Kurstyp: Ren forskarutbildningskurs
Undervisningsspråk: English
The aim of the course is for the student to acquire advanced knowledge about NMR relaxation theory and applications in studies of bio-macromolecular structure and dynamics. The course focuses on methods for studying proteins, but the underlying theory is equally applicable to essentially any molecule in the liquid phase.
Kunskap och förståelse
För godkänd kurs skall doktoranden
Färdighet och förmåga
För godkänd kurs skall doktoranden
Värderingsförmåga och förhållningssätt
För godkänd kurs skall doktoranden
The course begins with basic theory on NMR relaxation, including the random-phase model for transverse relaxation, Bloch-Wangsness-Redfield theory, stochastic processes, correlation functions and spectral density functions, relaxation mechanisms, interference effects, and chemical exchange effects. The course then covers the experimental approaches to study molecular dynamics using NMR relaxation.
J, C., WJ, F., AG, P., M, R. & NJ, S.: Protein NMR Spectroscopy. Principles and Practice, 2nd Ed.. Elsevier Academic Press, 2007.
The course text book will be complemented by review articles.
Undervisningsformer: Seminarier, projekt, litteraturkurs som självstudier. The course is organized around seminars or discussion meetings where groups of students present the assigned reading material. The course also includes a project, where each student will analyze an NMR pulse sequence from the research literature.
Examinationsformer: Skriftlig rapport, inlämningsuppgifter.
Students will solve home assignments during the course.
At the end of the course, each student will be assigned a recent research publication, which should be analyzed in detail using the theory learnt in the course and described in a written report.
Betygsskala: Underkänd, godkänd
Examinator:
Förkunskapskrav: Required: KFKN01, Magnetic Resonance — Spectroscopy and Imaging, or another course at the corresponding level
Recommended: Advanced NMR spectroscopy.
Förutsatta förkunskaper: Mathematics corresponding to the K or B programs at LTH
The course will be offered provided that a sufficient number of students have shown an interest. Typically, this would entail at least 3-4 students in order for the peer instruction element to work well.
Kursansvariga: