Course Syllabus for

NMR Relaxation: Theory and Applications
NMR-relaxation: teori och tillämpningar

KFK005F, 10 credits

Valid from: Spring 2021
Decided by: Margareta Sandahl
Date of establishment: 2020-03-19

General Information

Division: Biophysical Chemistry
Course type: Third-cycle course
Teaching language: English


The aim of the course is for the student to acquire advanced knowledge about NMR relaxation theory and applications in studies of bio-macromolecular structure and dynamics. The course focuses on methods for studying proteins, but the underlying theory is equally applicable to essentially any molecule in the liquid phase.


Knowledge and Understanding

For a passing grade the doctoral student must

Competences and Skills

For a passing grade the doctoral student must

Judgement and Approach

For a passing grade the doctoral student must

Course Contents

The course begins with basic theory on NMR relaxation, including the random-phase model for transverse relaxation, Bloch-Wangsness-Redfield theory, stochastic processes, correlation functions and spectral density functions, relaxation mechanisms, interference effects, and chemical exchange effects. The course then covers the experimental approaches to study molecular dynamics using NMR relaxation.

Course Literature

J, C., WJ, F., AG, P., M, R. & NJ, S.: Protein NMR Spectroscopy. Principles and Practice, 2nd Ed.. Elsevier Academic Press, 2007.
The course text book will be complemented by review articles.

Instruction Details

Types of instruction: Seminars, project, self-study literature review. The course is organized around seminars or discussion meetings where groups of students present the assigned reading material. The course also includes a project, where each student will analyze an NMR pulse sequence from the research literature.

Examination Details

Examination formats: Written report, written assignments. Students will solve home assignments during the course. At the end of the course, each student will be assigned a recent research publication, which should be analyzed in detail using the theory learnt in the course and described in a written report.
Grading scale: Failed, pass

Admission Details

Admission requirements: Required: KFKN01, Magnetic Resonance — Spectroscopy and Imaging, or another course at the corresponding level Recommended: Advanced NMR spectroscopy.
Assumed prior knowledge: Mathematics corresponding to the K or B programs at LTH

Further Information

The course will be offered provided that a sufficient number of students have shown an interest. Typically, this would entail at least 3-4 students in order for the peer instruction element to work well.

Course Occasion Information

Contact and Other Information

Course coordinators:

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