KOKN01F

Temporary

Medicinal Chemistry

7.5

Course given jointly for second and third cycle

7719 (Centre for Analysis and Synthesis (CAS))

 -02-03

FN2/Eva Nordberg Karlsson

English

Every autumn semester

The aim of the course is to give deep knowledge in and broad understanding of medicinal chemistry and pharmacological principles from a molecular perspective.

The course discusses the most common target molecules for drug development, general pharmacodynamic/pharmacokinetic principles and strategies for drug discovery and development. It integrates organic, physical, theoretical and biochemistry to describe how a given drug molecule can interact with disease-relevant target molecules, as well as how drug molecules can be chemically optimised with respect to pharmacodynamic and pharmacokinetic properties. Relationships between chemical structure and biological activity are central in the teaching content. This is exemplified in the course with antivirals, antibiotics, cancer drugs, PNS/CNS drugs (adrenergic, cholinergic, and opiate receptors) and ulcer drugs. Biologicals are describes, discussed,an d compared with small organic molecules from a drug perspective.

be able to describe the most common strategies for drug discovery and development
be able to describe common target molecules for drug development
be able to describe basic pharmacodynamic and pharmacokinetic concepts from a molecular perspective
be able to explain relationships between chemical structure and biological activity
be able to describe chemical principles for design and development of drug molecules
be able to name some of the most common drug compounds and their areas of use

be able to discuss orally and in writing chemical, physical, and pharmacokinetic properties of given drug molecules
be able to describe and discuss drug action mechanisms from a molecular perspetive based on conformational analysis, steroechemistry, acid-base chemstry and ligand-macromolecule interactions
be able to analyse a given molecular structure in terms of potential as a drug candidate

be able to analyse and judge a given molecular structure as potential drug candidat
be able to analyse his/hers views and arguments for the judgement of a molecular structure as a potential drug candidate

Lectures

Exercises

Self-study literature review

Written exam

Failed, pass

KOO101 Fundamental chemistry, KOKA01 General and Inorganic Chemistry KOK012 or KOKA05 Organic chemistry KFKA05 Molecular Driving Forces 1: Thermodynamics, KFK080 Thermodynamics, FAFA05 Physics - Waves, Thermodynamics and Atomic Physics or a corresponding course KBK011 Biokemi, KBKA05 Technical Biology, TEK295 Biology of the Cell or a corresponding course

Patrick, Graham L.: An Introduction to Medicinal Chemistry. Oxford University Press, 2013. ISBN 9780199697397.

KOKN01F

 -02-03

FN2/Eva Nordberg Karlsson