Gäller från och med: Autumn 2013
Beslutad av: FN2/Eva Nordberg Karlsson
Datum för fastställande: 2013-09-06
Avdelning: Chemical Engineering
Kurstyp: Ren forskarutbildningskurs
Undervisningsspråk: English
A quantitative description of microbial metabolism is the basis for development of new fermentation products and improvement of production strains. The integration of analysis at different levels of microbial metabolism (substrate fluxes, enzyme catalytic systems, regulatory systems, affectors) is the field of System Biology – or with a more applied focus - Systems Biotechnology. This course aims at the quantative understanding of microbial processes, primarily in terms of analyzing carbon flux distributions, and the (mathematical) tools available.
Kunskap och förståelse
För godkänd kurs skall doktoranden
Färdighet och förmåga
För godkänd kurs skall doktoranden
Värderingsförmåga och förhållningssätt
För godkänd kurs skall doktoranden
The focus of the course is the stoichiometric modeling of metabolic network (flux analysis), but to some extent also dynamic network analysis will be looked at.
The course will be based on the seminal books by Bernhard Palsson on Systems Biology (Systems Biology – Properties of Reconstructed Networks, Cambridge University Press, 2006 and Systems Biology – Simulation of Dynamic Network States, Cambridge University Press, 2011) with most focus on the first book
Undervisningsformer: Seminarier, laborationer, projekt. Hands-on experience on simulation tools, like FluxOpt and COBRA, will be included to illustrate simulations tools available.
Examinationsform: Seminarieföredrag av deltagarna.
Regular seminars will be arranged in which the course participants will prepare and present course topics and simulation problems. Each participant will be assigned a specific modeling and simulation problem to be treated in a written report. The report and the seminar participation constitute the examination in the course.
Betygsskala: Underkänd, godkänd
Examinator:
Förkunskapskrav: The course is open to PhD students in the fields of biotechnology,microbiology, chemical engineering, automatic control or chemistry.
Förutsatta förkunskaper: The course assumes some familiarity with linear algebra and differential equations as well as basic knowledge in biochemistry.
The course is given in the Spring 2013 Gunnar Lidén (046 – 222 0862) gunnar.liden@chemeng.lth.se
Kursansvariga: