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Third-Cycle Courses

Faculty of Engineering | Lund University

Details for the Course Syllabus for Course KETN30F valid from Autumn 2018

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General
Aim
  • Development of new biotechnical processes requires analysis of the microbial metabolism as well as the bioreactor. The aim of this course is to provide the student with understanding and skills to enable them to analyse a biotechnical process in a quantitative fashion. This will provide the basis for the design and scale-up of processes in biotechnology.
Contents
  • The course treats processes in biotechnology in a quantitative fashion on both the cellular and the reactor level. The following topics are covered: Metabolic reactions, stoichiometry, the C-mol concept, degree of reduction, thermodynamics in microbial systems, modelling of metabolic networks, reaction kinetics, design of biotechnical processes, mass transfer, and scale-up of biotechnical processes.
Knowledge and Understanding
  • For a passing grade the doctoral student must
  • be able to describe the principles behind global metabolic networks analysis, and describe the application of metabolic network analysis in the design of genetically modified production organisms
    be able to describe the interaction between physical transport phenomena and the microbial metabolism in a bioreactor
    be able to identify critical factors in the scale-up of processes in biotechnology, and qualitatively compare different process options
Competences and Skills
  • For a passing grade the doctoral student must
  • be able to quantitatively analyse experimental results on the macro-level, e.g. by making carbon- and degree of reduction balances
    be able to set up stoichiometric network models for metabolic networks
    be able to model microbial kinetics
    be able to execute reaction engineering calculations for the design of bioreactors, including size, stirrer effect, mass transfer capacity, and cooling requirements
    be able to make a reasonable choice of reactor, substrate, and production organism for a given biotechnical process
Judgement and Approach
  • For a passing grade the doctoral student must
  • be able to assess the usefulness of quantitative models of biological processes within the research topic of the PhD student
Types of Instruction
  • Lectures
  • Seminars
  • Exercises
  • Study visit
  • This is also an advanced course within the engineering programmes of the Faculty of Engineering (B and K)
Examination Formats
  • Written exam
  • Written assignments
  • Failed, pass
Admission Requirements
  • Accepted to graduate studies within chemistry, chemical engineering, biotechnology or closely related fields
Assumed Prior Knowledge
Selection Criteria
Literature
  • Villadsen, J., Nielsen, J. & Lidén, G.: Bioreaction Engineering Principles. Springer, 2011. ISBN 9781441996879.
Further Information
  • Contact: Gunnar Liden, Chemical engineering
    gunnar.liden@chemeng.lth.se
Course code
  • KETN30F
Administrative Information
  • 2018-09-06
  • Margareta Sandahl

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