Frontiers in Organic Synthesis
Fronter i organisk syntes

KAS020F, 7.5 credits

Valid from: Spring 2020
Decided by: Margareta Sandahl
Date of establishment: 2020-03-19

General Information

Division: Centre for Analysis and Synthesis (CAS)
Course type: Third-cycle course
Teaching language: English

Aim

The course aims to deepen and broaden the students knowledge of modern organic synthesis strategies and methods. The course will cover methods with respect to synthesis planning, retrosynthetic analysis, and the synthon approach with respect to functional group strategies and stereochemical strategies, as well as target structure and topology.

Goals

Knowledge and Understanding

For a passing grade the doctoral student must be able to describe different strategies for planning multi-step syntheses.

Competences and Skills

For a passing grade the doctoral student must

• be able to apply selected synthesis planning strategies to reach comprehensive retro-synthetic analyses.
• be able to propose a viable synthetic plan based on modern chemical reactions and on a retro-synthetic analysis.

Judgement and Approach

For a passing grade the doctoral student must

• be able to compare and evaluate merits of different retro-synthetic analyses towards a given target molecule.
• be able to compare and evaluate scope and limitations of alternative reagents chosen for transformations within a proposed organic synthesis sequence.

Course Contents

Seminars on selected topics in advanced contemporary organic synthesis planning and retro-synthetic analysis. Each student will present an in-depth seminar on a topic within the course. Topics will be selected by the student with advise from course teachers. Part of the presentation assignment is feedback from peers and teachers.

Course Literature

Nicolaou, K. C. & Chen, Jason S.: Classics in Total Synthesis III: Further Targets, Strategies, Methods. John Wiley & Sons, 2011. ISBN 9783527329571.
Classics in Total Synthesis III: Further Targets, Strategies, Methods. Selected original and review publications.

Instruction Details

Types of instruction: Seminars, self-study literature review

Examination Details

Examination formats: Seminars given by participants, miscellaneous. Active participation in seminars (passed/not passed). Active attendance on presentation assignments by other students and opposition on one presentation (passed/not passed) Presentation and discussion of an assignment (passed/not passed). Final examination with questions in connection with the presentations (passed/not passed).
Grading scale: Failed, pass
Examiner:

Admission Details

Assumed prior knowledge: KAS003F or equivalent

Course Occasion Information

Contact and Other Information

Course coordinators:

• Ulf Nilsson <ulf.nilsson@chem.lu.se>
• Kenneth Wärnmark <kenneth.warnmark@chem.lu.se>