Course Syllabus for

Advanced NMR Spectroscopy
Avancerad NMR-spektroskopi

KFK001F, 10 credits

Valid from: Autumn 2020
Decided by: Margareta Sandahl
Date of establishment: 2020-03-19

General Information

Division: Biophysical Chemistry
Course type: Third-cycle course
Teaching language: English


The aim of the course is for the student to acquire advanced knowledge about Nuclear Magnetic Resonance (NMR) theory and applications in studies of bio-macromolecular structure and dynamics. The course focuses on methods for studying proteins, but the underlying theory is equally applicable to essentially any molecule in the liquid phase.


Knowledge and Understanding

For a passing grade the doctoral student must

Competences and Skills

For a passing grade the doctoral student must

Judgement and Approach

For a passing grade the doctoral student must

Course Contents

The course begins with basic theory on NMR, including an introduction to quantum mechanics, quantum statistical mechanics, the density matrix and product operator formalisms. The course then covers the theory of multi-dimensional spectroscopy, including frequency labeling of coherences, coherence transfer and mixing, and coherence pathway selection. The course also covers experimental techniques and practical aspects, including data acquisition and data processing.

Course Literature

J, C., WJ, F., AG, P., M, R. & NJ, S.: Protein NMR Spectroscopy. Principles and Practice, 2nd Edition. Elsevier Academic Press, 2007. ISBN 9780121644918.
The textbook will be complemented with review articles distributed during the course.

Instruction Details

Types of instruction: Seminars, project, self-study literature review. The course is organized around seminars or discussion meetings where groups of students present the assigned reading material. The course also includes a project, where each student will analyze an NMR pulse sequence from the research literature.

Examination Details

Examination formats: Written report, written assignments. Students will solve home assignments during the course. At the end of the course, each student will be assigned a recent research publication, which should be analyzed in detail using the theory learnt in the course and described in a written report.
Grading scale: Failed, pass
Examiner: Professor Mikael Akke

Admission Details

Admission requirements: KFKN01, Magnetic Resonance — Spectroscopy and Imaging, or an equivalent course.
Assumed prior knowledge: Mathematics corresponding to curriculum in the K or B programs at LTH.

Further Information

The course will be offered provided that a sufficient number of students have shown an interest. Normally, this would entail at least 3-4 students in order for the peer instruction element to work well.

Course Occasion Information

Start date: 2024-04-15
End date: 2024-06-20
Course pace: Full time

Contact and Other Information

Course coordinator: Mikael Akke <>

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