Medicinal Chemistry
Läkemedelskemi

KOKN01F, 7.5 credits

Valid from: Autumn 2013
Decided by: FN2/Eva Nordberg Karlsson
Date of establishment: 2014-02-03

General Information

Division: Centre for Analysis and Synthesis (CAS)
Course type: Course given jointly for second and third cycle
The course is also given at second-cycle level with course code: KOKN01
Teaching language: English

Aim

The aim of the course is to give deep knowledge in and broad understanding of medicinal chemistry and pharmacological principles from a molecular perspective.

Goals

Knowledge and Understanding

For a passing grade the doctoral student must

• be able to describe the most common strategies for drug discovery and development
• be able to describe common target molecules for drug development
• be able to describe basic pharmacodynamic and pharmacokinetic concepts from a molecular perspective
• be able to explain relationships between chemical structure and biological activity
• be able to describe chemical principles for design and development of drug molecules
• be able to name some of the most common drug compounds and their areas of use

Competences and Skills

For a passing grade the doctoral student must

• be able to discuss orally and in writing chemical, physical, and pharmacokinetic properties of given drug molecules
• be able to describe and discuss drug action mechanisms from a molecular perspetive based on conformational analysis, steroechemistry, acid-base chemstry and ligand-macromolecule interactions
• be able to analyse a given molecular structure in terms of potential as a drug candidate

Judgement and Approach

For a passing grade the doctoral student must

• be able to analyse and judge a given molecular structure as potential drug candidat
• be able to analyse his/hers views and arguments for the judgement of a molecular structure as a potential drug candidate

Course Contents

The course discusses the most common target molecules for drug development, general pharmacodynamic/pharmacokinetic principles and strategies for drug discovery and development. It integrates organic, physical, theoretical and biochemistry to describe how a given drug molecule can interact with disease-relevant target molecules, as well as how drug molecules can be chemically optimised with respect to pharmacodynamic and pharmacokinetic properties. Relationships between chemical structure and biological activity are central in the teaching content. This is exemplified in the course with antivirals, antibiotics, cancer drugs, PNS/CNS drugs (adrenergic, cholinergic, and opiate receptors) and ulcer drugs. Biologicals are describes, discussed,an d compared with small organic molecules from a drug perspective.

Course Literature

Patrick, Graham L.: An Introduction to Medicinal Chemistry. Oxford University Press, 2013. ISBN 9780199697397.

Instruction Details

Types of instruction: Lectures, exercises, self-study literature review

Examination Details

Examination format: Written exam
Grading scale: Failed, pass
Examiner:

Admission Details

Assumed prior knowledge: KOO101 Fundamental chemistry, KOKA01 General and Inorganic Chemistry KOK012 or KOKA05 Organic chemistry KFKA05 Molecular Driving Forces 1: Thermodynamics, KFK080 Thermodynamics, FAFA05 Physics - Waves, Thermodynamics and Atomic Physics or a corresponding course KBK011 Biokemi, KBKA05 Technical Biology, TEK295 Biology of the Cell or a corresponding course

Course Occasion Information

Contact and Other Information

Course coordinators:
Web page: http://www.chem.lu.se/education/Kemiteknik&Bioteknik/MedChem/MedChem.html